Lewy body formation in Parkinson's disease: Neurodegeneration or neuroprotection?
نویسندگان
چکیده
منابع مشابه
[Lewy body formation in Parkinson's disease: neurodegeneration or neuroprotection?].
The histological hallmark of Parkinson's disease (PD) is the presence of fibrillar aggregates called Lewy bodies (LBs). LB formation has been considered to be a marker for neuronal degeneration, because neuronal loss is found in the predilection sites for LBs. To date, more than 70 molecules have been identified in LBs, in which alpha-synuclein is a major constituent of LB fibrils. Alpha-synucl...
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Parkinson’s disease is an age related neurodegenerative and movement disorder affecting 1-3% of individuals above the age of 60 years. Parkinson’s disease is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of Lewy bodies in the surviving neurons. Lewy bodies are present in the central and sympathetic nervous systems, and it is...
متن کاملCortical Lewy body disease.
C ortical Lewy body disease is a pathological observation rather than a distinct clinicopathological entity. Cortical Lewy bodies (CLB) are typically found in Parkinson’s disease and dementia with Lewy bodies (DLB), although they may also occur in other neurological disorders. Unlike their brain stem counterparts, CLB are less distinctive and are poorly visualised using conventional histochemic...
متن کامل[Diffuse Lewy body disease].
Diffuse Lewy body disease (DLBD) has been studied from various viewpoints and, although clinical diagnostic criteria for DLBD have been proposed, diagnosis remains difficult. DLBD has been reported to be the second most common form of dementia in the aged, following Alzheimer-type dementia. It has, however, been clinically under-diagnosed. Therefore, the search for diagnostic markers for DLBD m...
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The objective of this work is to describe the neuropathological findings of a patient clinically presenting with rapidly progressive nonspecific neurological symptoms suggestive of Creutzfeldt-Jakob disease. Methods used were clinical description with laboratory analyses, repeated electroencephalogram, cerebral computed tomography, magnetic resonance imaging studies and details on neuropatholog...
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ژورنال
عنوان ژورنال: Rinsho Shinkeigaku
سال: 2008
ISSN: 0009-918X,1882-0654
DOI: 10.5692/clinicalneurol.48.981